Levels of human proteins in plasma associated with acute paediatric malaria

Malaria Journal

Table 3 Proteins with differential levels observed between severe cases that presented with febrile convulsions compared to cerebral malaria

Primary biological process	Gene	Uniprot ID	Gene description	p-value	Antibody
Erythrocyte morphology	ANK1	P16157	Ankyrin 1	1e−02	HPA004842
Erythrocyte morphology	MPP1	Q00013	Membrane palmitoylated protein 1	1e−03	HPA076675
Acute phase response	CD14	P08571	CD14 molecule	4e−03	HPA001887+
Cell cycle regulation	CDK14	O94921	Cyclin dependent kinase 14	3e−03	HPA015267
ECM disassembly	ELANE	P08246	Neutrophil elastase	4e−03	MAB91671 R&D+

Information about the five proteins showing differential levels in patients with febrile convulsions compared to cerebral malaria, grouped on primary biological function, and unadjusted p-values based on Wilcoxon rank-sum test. All five proteins showed increased levels in patients with febrile convulsions compared to cerebral malaria. Proteins supported by multiple antibodies are marked + in the antibody column (see also Additional files 5, 12)

ISSN: 1475-2875