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Table 4 CYP2D6 allele frequencies in Karen compared with frequencies previously described in other ethnic populations

From: Real time PCR detection of common CYP2D6 genetic variants and its application in a Karen population study

Population Year n Methods C100T
P34S
(*10)
C1039T G1661C G1846A
Splicing
(*4)
C2850T
R296C
(*2)
G4180C
S486T
Gene conversion
(*36)
Deletion
(*5)
Duplications
Asian
 Karen (current study) 2017 70 DSP/ASO 0.40 0.43 0.76 0.02 0.33 0.76 0.01 0.03 0.01
 Thai [44] 2011 286 M/DHPLC 0.45 ND ND 0.01 0.10 ND 0.16 0.04 0.004
 Thai [49] 2012 48 AmpliChip 0.44 ND ND 0.01 0.10 ND 0.01 0.04 ND
 Thai [50] 2013 114 AmpliChip 0.46 ND ND 0.01 0.10 ND 0.01 0.04 ND
 Thai [51] 2013 233 Amplichip 0.48 ND ND 0.01 0.09 ND 0.01 0.05 0.004
 Thai [45] 2016 84 Luminex xTag 0.52 ND ND 0.01 0.06 ND ND ND 0.06
 Chinese [52] 2002 223 ASA 0.51 ND ND 0.002 ND ND ND 0.07 0.01
 Chinese [53] 2008 400 Sequencing 0.53 ND ND 0.001 0.11 ND ND 0.05 0.02
 Hong Kong Chinese [54] 2000 119 PCR–RFLP 0.65 ND ND 0.00 0.08 ND ND 0.05 ND
 Vietnamese [55] 2010 122 mSBE 0.57 ND ND ND 0.08 ND ND 0.06 0.00
 Japanese [56] 1999 98 PCR 0.41 ND ND 0.02 0.09 ND ND 0.06 ND
 Japanese [57] 2000 412 PCR–RFLP 0.38 ND ND 0.002 0.13 ND ND 0.05 0.01
 Japanese [58] 2003 162 ASA-RFLP 0.38 ND ND 0.00 0.13 ND 0.01 0.06 ND
 Korean [59] 2006 400 Sequencing 0.45 ND ND 0.003 0.10 ND ND 0.06 0.01
 Korean [60] 2009 758 Sequencing 0.46 ND ND ND 0.10 ND ND 0.06 0.01
 Korean [61] 2011 766 SNaPshot 0.43 ND ND 0.001 0.12 ND ND 0.06 0.01
 South India [62] 2006 447 PCR–RFLP 0.10 ND ND 0.07 0.35 ND ND 0.02 ND
Caucasian
 Germany [63] 1997 589 PCR–RFLP 0.02 ND ND 0.21 0.32 ND ND 0.02 0.007
 Mexican-American [64] 2001 349 PCR–RFLP 0.07 ND ND 0.10 0.23 ND ND 0.02 0.01
 Spanish [65] 2006 105 RT-PCR 0.02 ND ND 0.14 0.40 ND ND 0.03 0.04
African
 African-American [66] 2001 154 PCR–RFLP 0.08 ND ND 0.08 0.27 ND ND 0.06 0.02
 African-American [67] 2006 222 AmpliChip 0.04 ND ND 0.07 0.05 ND 0.005 0.06 0.05
 African-American [68] 2013 75 mPCR 0.03 ND ND 0.08 0.29 ND ND 0.09 ND
  1. Allele frequencies of CYP2D6*2, *4, *5, *10 and *36 were calculated based on the presence of C2850T, G1846A, entire CYP2D6 gene deletion, C100T and gene conversion, respectively
  2. n, the number of subjects ND, allele not determined in reference study; DSP/ASO, direct sequencing of PCR-reamplified products and allele-specific oligonucleotide probes real-time SNPs genotyping; ASA, allele-specific amplification assay; mPCR or SBE, multiplex PCR or single-base extension; M/DHPLC, multiplex PCR coupled with semi-quantitative denaturing high-performance liquid chromatography