Dose band | Bodyweight (kg) | Total dose (mg) | Number of patients | Dose (mg)/bodyweight (kg) (mean, SD) |
---|---|---|---|---|
1 | 10–16 | 150 | 4 | 11.1 (2.6) |
2 | 17–22 | 225 | 5 | 11.6 (1.0) |
3 | 23–28 | 300 | 3 | 11.8 (1.1) |
4 | 29–34 | 375 | 5 | 11.9 (0.8) |
5 | 35–41 | 450 | 5 | 12.0 (0.6) |
6 | 42–47 | 525 | 4 | 11.5 (0.3) |
7 | 48–53 | 600 | 11 | 11.9 (0.5) |
8 | 54–59 | 675 | 6 | 12.2 (0.3) |
9 | 60–65 | 750 | 4 | 12.0 (0.4) |
10 | 66–72 | 825 | 1 | 11.4 (–) |
11 | 73–77 | 900 | 0 | – |
12 | 78–85 | 975 | 1 | 11.9 (–) |