Skip to main content

Table 3 Parasitological response

From: Plasmodium falciparum artemisinin resistance monitoring in Sabah, Malaysia: in vivo therapeutic efficacy and kelch13 molecular marker surveillance

Variable

Artesunate, n = 49

Parasitological response

 24 h

  Number negative

29

  % (CI 95)

59.2 (44.2–73.0)

 48 h

  n

44

  % (CI 95)

89.8 (77.8–96.6)

 72 h

  n

49

  % (CI 95)

100 (92.7–100)

Parasite clearance time (PCT)

Median hours

25.6

(IQR)[range]

(18.5–42)[7.9–73.9]

Slope of curve (k) for loge

Normalised parasite clearance*

 Mean (k) constant (CI 95)

0.26 (0.20–0.32)

Slope of curve (k) half-life

 Median hours (IQR)

2.7 (2.2–3.5)

Slope of curve (k) half-life > 5 h

 n (%)

3 (6.7)

Lag phase present

 n (%)

9 (20)

Lag phase duration

 Median hours (IQR)

7.7 (7.3–8.7)

PCT50

 Median hours (IQR)

4.3 (2.0–8.4)

PCT90

 Median hours (IQR)

10.8 (6.8–15.6)

PCT95

 Median hours (IQR)

13.4 (9.0–18.6)

PCT99

 Median hours (IQR)

19.7 (14.3–25.6)

  1. * 45 (92%) had data at ≥ 3 time points allowing parasite clearance analysis