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Table 3 Parasitological response

From: Plasmodium falciparum artemisinin resistance monitoring in Sabah, Malaysia: in vivo therapeutic efficacy and kelch13 molecular marker surveillance

Variable Artesunate, n = 49
Parasitological response
 24 h
  Number negative 29
  % (CI 95) 59.2 (44.2–73.0)
 48 h
  n 44
  % (CI 95) 89.8 (77.8–96.6)
 72 h
  n 49
  % (CI 95) 100 (92.7–100)
Parasite clearance time (PCT)
Median hours 25.6
(IQR)[range] (18.5–42)[7.9–73.9]
Slope of curve (k) for loge
Normalised parasite clearance*
 Mean (k) constant (CI 95) 0.26 (0.20–0.32)
Slope of curve (k) half-life
 Median hours (IQR) 2.7 (2.2–3.5)
Slope of curve (k) half-life > 5 h
 n (%) 3 (6.7)
Lag phase present
 n (%) 9 (20)
Lag phase duration
 Median hours (IQR) 7.7 (7.3–8.7)
PCT50
 Median hours (IQR) 4.3 (2.0–8.4)
PCT90
 Median hours (IQR) 10.8 (6.8–15.6)
PCT95
 Median hours (IQR) 13.4 (9.0–18.6)
PCT99
 Median hours (IQR) 19.7 (14.3–25.6)
  1. * 45 (92%) had data at ≥ 3 time points allowing parasite clearance analysis