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Table 4 Accuracy of RDTs and peripheral thick blood smear in comparison with placental tissue impression smear for detecting placental malaria infection according to the parity

From: Accuracy of One Step malaria rapid diagnostic test (RDT) in detecting Plasmodium falciparum placental malaria infection in women living in Yaoundé, Cameroon

 

Primi

Secundi

Multi

p–value

Pbs

 Sensitivity (%)

88.88 [51.75–99.72]

70.0 [34.75–93.33]

85.7 [42.13–99.64]

0.009

 Specificity (%)

100 [94.22–100]

100 [89.42–100]

100 [95.26–100]

 PPV (%)

100 [63.06–100]

100 [59.04–100]

100 [54.07–100]

 NPV (%)

98.40 [91.47–99.96]

91.66 [77.53–98.25]

98.79 [92.98–100]

0.19

pLDH based RDT

 Sensitivity (%)

55.55 [21.20–86.30]

60.00 [26.24–87.84]

71.43 [29.04–96.33]

0.05

 Specificity (%)

100 [94.22–1.00]

100 [89.42–100]

100 [95.26–100]

 PPV (%)

100 [47.82–1.00]

100 [54.07–100]

100 [47.82–100]

 NPV (%)

93.10 [85.20–98.32]

89.19 [74.58–96.97]

98.27 [91.04–99.69]

0.03

HRP-II based RDT

 Sensitivity (%)

88.88 [51.75–99.72]

100 [69.15–100]

100 [59.04–100]

< 0.0001

 Specificity (%)

96.77 [88.83–99.61]

100 [89.42–100]

94.74 [87.07–98.55]

0.05

 PPV (%)

80.00 [44.39–97.48]

100 [69.15–100]

63.64 [30.79–89.07]

< 0.0001

 NPV (%)

98.21 [91.20–99.96]

100 [89.42–100]

100 [95.01–100]

0.13

HRP-II based RDT + Pbs

 Sensitivity (%)

88.88 [51.75–99.72]

100 [69.15–100]

100 [59.04–100]

< 0.0001

 Specificity (%)

96.77 [88.83–99.61]

100 [89.42–100]

94.74 [87.07–98.55]

0.05

 PPV (%)

80.00 [44.39–97.48]

100 [69.15–100]

63.64 [30.79–89.07]

< 0.0001

 NPV (%)

98.21 [91.20–99.96]

100 [89.42–100]

100 [95.01–100]

0.13

  1. Values in square brackets represent 95% confidence intervals. Chi Square test was used to compare the performance of different malaria diagnostic methods between primipara, secundipara and multipara women
  2. Primi primipara women, Secundi secundipara women, Multi multipara women, PPV positive predictive value, NPV negative predictive value, Pbs peripheral blood smear