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Table 4 Accuracy of RDTs and peripheral thick blood smear in comparison with placental tissue impression smear for detecting placental malaria infection according to the parity

From: Accuracy of One Step malaria rapid diagnostic test (RDT) in detecting Plasmodium falciparum placental malaria infection in women living in Yaoundé, Cameroon

  Primi Secundi Multi p–value
Pbs
 Sensitivity (%) 88.88 [51.75–99.72] 70.0 [34.75–93.33] 85.7 [42.13–99.64] 0.009
 Specificity (%) 100 [94.22–100] 100 [89.42–100] 100 [95.26–100]
 PPV (%) 100 [63.06–100] 100 [59.04–100] 100 [54.07–100]
 NPV (%) 98.40 [91.47–99.96] 91.66 [77.53–98.25] 98.79 [92.98–100] 0.19
pLDH based RDT
 Sensitivity (%) 55.55 [21.20–86.30] 60.00 [26.24–87.84] 71.43 [29.04–96.33] 0.05
 Specificity (%) 100 [94.22–1.00] 100 [89.42–100] 100 [95.26–100]
 PPV (%) 100 [47.82–1.00] 100 [54.07–100] 100 [47.82–100]
 NPV (%) 93.10 [85.20–98.32] 89.19 [74.58–96.97] 98.27 [91.04–99.69] 0.03
HRP-II based RDT
 Sensitivity (%) 88.88 [51.75–99.72] 100 [69.15–100] 100 [59.04–100] < 0.0001
 Specificity (%) 96.77 [88.83–99.61] 100 [89.42–100] 94.74 [87.07–98.55] 0.05
 PPV (%) 80.00 [44.39–97.48] 100 [69.15–100] 63.64 [30.79–89.07] < 0.0001
 NPV (%) 98.21 [91.20–99.96] 100 [89.42–100] 100 [95.01–100] 0.13
HRP-II based RDT + Pbs
 Sensitivity (%) 88.88 [51.75–99.72] 100 [69.15–100] 100 [59.04–100] < 0.0001
 Specificity (%) 96.77 [88.83–99.61] 100 [89.42–100] 94.74 [87.07–98.55] 0.05
 PPV (%) 80.00 [44.39–97.48] 100 [69.15–100] 63.64 [30.79–89.07] < 0.0001
 NPV (%) 98.21 [91.20–99.96] 100 [89.42–100] 100 [95.01–100] 0.13
  1. Values in square brackets represent 95% confidence intervals. Chi Square test was used to compare the performance of different malaria diagnostic methods between primipara, secundipara and multipara women
  2. Primi primipara women, Secundi secundipara women, Multi multipara women, PPV positive predictive value, NPV negative predictive value, Pbs peripheral blood smear