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Table 3 Number of cases with each pfdhfr*/pfdhps** combined genotype* from different districts in Indonesia in two study periods

From: Origins and spread of novel genetic variants of sulfadoxine–pyrimethamine resistance in Plasmodium falciparum isolates in Indonesia

Year Island Province District n***
(mixed cases)
Pfdhfr/pfdhps combined genotypes
ANCSI* ANCNI ANRNI
SAKAA** SGEAA SAKAA SGKGA SAKAA SGKAA SGKGA SGEAA
2004–2006 Sumatera Riau Indragiri Hilir 6      6    
Kalimantan East Kalimantan Paser 25        1 4
    (11)         (6a+3b)/2
Java East Java Pacitan 29         
Lombok West Nusa Tenggara West Lombok 44      41    
    (1)      (1a)/2    (1a)/2
Sumbawa West Nusa Tenggara Sumbawa 77 1   5   43 8   6
    (3) (2a)/2     (1b)/2 (2a)/2   (1b)/2
Papua Papua Jayapura 9         9
    190 1   5   90 8 1 19
    (15) (2)/2     (2)/2 (2)/2   (1)/2
Year Island Province District n***
(mixed cases)
Pfdhfr/pfdhps combined genotypes
ANRNI ANRNL
SGEAA
(588F)
SGEGA SGTGA SGKAA SGKGA SGEAA SGEGA SGTGA
2004–2006 Sumatera Riau Indragiri Hilir 6         
Kalimantan East Kalimantan Paser 25    15      5
    (11)   (6a)/2 (3b+2c)/2      (2c)/2
Java East Java Pacitan 29    19   5 4 1  
Lombok West Nusa Tenggara West Lombok 44 3        
    (1) 12   2      
Sumbawa West Nusa Tenggara Sumbawa 77         
    (3)         
Papua Papua Jayapura 9         
    190 15   36   5 4 1 5
    (15)   (6)/2 (5)/2      (2)/2
Year Island Province District n***
(mixed cases)
Pfdhfr/pfdhps combined genotypes
ANCSI* ANCNI ANRNI
SAKAA** SGEAA SAKAA SGKGA SAKAA SGKAA SGKGA SGEAA
2009–2012 Sumatera Riau Indragiri Hilir 1       1   
Sumatera Jambi Merangin 1         
Kalimantan Middle Kalimantan Seruyan 19         
Kalimantan South Kalimantan Banjar 56    1 1    4 5
    (3)     (1a)/2    (1b)/2  
Lombok West Nusa Tenggara West Lombok 48      47    1
Timor East Nusa Tenggara Timor Tengah Selatan 3      3    
Sulawesi Gorontalo Gorontalo 2       1   
Papua Papua Jayapura 46 1 4    16    21
    176 1 4 1 1 66 2 4 27
    (3)     (1)/2    (1)/2  
Year Island Province District n***
(mixed cases)
Pfdhfr/pfdhps combined genotypes
ANRNI ANRNL
SGEAA
(588F)
SGEGA SGTGA SGKAA SGKGA SGEAA SGEGA SGTGA
2009–2012 Sumatera Riau Indragiri Hilir 1         
Sumatera Jambi Merangin 1        1  
Kalimantan Middle Kalimantan Seruyan 19    1   11 6 1  
Kalimantan South Kalimantan Banjar 56 8 1 17 10     9
    (3) (1a+1b)/2      (1c)/2   (1c)/2
Lombok West Nusa Tenggara West Lombok 48         
Timor East Nusa Tenggara Timor Tengah Selatan 3         
Sulawesi Gorontalo Gorontalo 2 1        
Papua Papua Jayapura 46 4        
    176 13 1 18 10 11 6 2 9
    (3) (2)/2      (1)/2   (1)/2
  1. pfdhfr genotype are presented with the amino acids at the position of 16, 51, 59, 108, 164, and ANCSI is the wild type of pfdhfr
  2. ** pfdhps genotype are presented with the amino acids at the position of 436, 437, 540, 581, 613 (and 588), and SAKAA is the wild type of pfdhps. The underlined letters indicate amino acid substitutions
  3. *** Number of mixed infection cases are presented in brackets as (N), and each pair of the mixed case is presented with superscript as (Na)/2