Table 2 Genetic diversity of Plasmodium falciparum msp1 and msp2 among parasitaemic groups of symptomatic patients on Bioko Island, Equatorial Guinea (2011–2014)
Gene | Allelic type | Parasite density (no. of parasites/μl) | ||
|---|---|---|---|---|
< 1000 | 1000–9999 | ≥ 10,000 (%) | ||
n (%) | n (%) | n (%) | ||
(n = 14) | (n = 74) | (n = 93) | ||
msp1 | MAD20 | 1 (7.1) | 0 | 1 (1.1) |
K1/MAD20 | 3 (21.4) | 22 (29.7) | 25 (27.8) | |
K1/RO33 | 1 (7.1) | 1 (1.4) | 1 (1.1) | |
MAD20/RO33 | 0 | 4 (5.4) | 1 (1.1) | |
K1/MAD20/RO33 | 9 (64.3) | 46 (62.2) | 63 (70) | |
Total | 13 (92.9) | 73 (98.6) | 90 (49.72) | |
MOI | 3.07 | 3.63 | 3.48 | |
msp2 | 3D7 | 3 (21.4) | 25 (33.8) | 20 (21.5) |
FC27 | 1 (7.1) | 2 (2.7) | 1 (1.1) | |
3D7/FC27 | 7 (50) | 45 (60.8) | 69 (74.2) | |
Total | 7 (50) | 45 (60.8) | 69 (74.2) | |
MOI | 1.73 | 1.90 | 2.31 | |
Multiclonal isolates | 14 (100) | 74 (100) | 93 (100) | |
Overall MOI | 4.43 | 5.51 | 5.77 | |