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Table 1 Comparison of rapid diagnostic test (RDTs) HRP2 (First Response®) and pLDH/HRP2 (Combo®) with microscopy

From: Diagnostic capacity, and predictive values of rapid diagnostic tests for accurate diagnosis of Plasmodium falciparum in febrile children in Asante-Akim, Ghana

Tests results GS: Microscopya (n = 260) Prevalence Sensitivity (95% CI) Specificity (95% CI) PPV (95% CI) NPV (95% CI)
Positive Negative
HRP2
 Positive 77 6 31.3 (25.7–37.3) 95.1 (87.8–98.6) 96.6 (92.8–98.8) 92.8 (85.4–96.6) 97.7 (94.3–99.1)
 Negative 4 173
Combo
 Positive 78 3 31.2 (25.9–37.2) 96.3 (89.6–99.2) 98.3 (95.2–99.7) 96.3 (89.4–98.8) 98.3 (95.1–99.4)
 Negative 3 176
  1. GS gold standard, PPV positive predictive value, NPV negative predictive value, HRP2 histidine-rich protein 2, pLDH lactate dehydrogenase
  2. aMean parasite density 29,721.6/µL (300–99,500/µL), Trophozoites 50, Schizont 1