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Table 2 Comparison of rapid diagnostic test (RDTs) HRP2 (First Response®) and pLDH/HRP2 (Combo®) and microscopy with PCR

From: Diagnostic capacity, and predictive values of rapid diagnostic tests for accurate diagnosis of Plasmodium falciparum in febrile children in Asante-Akim, Ghana

Tests results

GS: PCR (n = 246)

Prevalence

Sensitivity (95% CI)

Specificity (95% CI)

PPV (95% CI)

NPV (95% CI)

Positive

Negative

HRP2

 Positive

72

10

39.8 (33.7–46.3)

73.5 (63.6–81.9)

93.2 (87.9–96.7)

87.8 (79.6–93.0)

84.2 (79.2–88.1)

 Negative

26

138

Combo

 Positive

71

9

39.8 (33.7–46.3)

72.5 (62.5–81.0)

93.9 (88.8–97.2)

88.6 (80.5–93.8)

83.7 (78.8–87.7)

 Negative

27

139

Microscopy

 Positive

70

9

39.8 (33.7–46.3)

71.4 (61.4–80.1)

93.9 (88.8–97.2)

88.6 (80.3–93.7)

83.2 (78.4–87.2)

 Negative

28

139

  1. GS gold standard, PCR polymerase chain reaction, PPV positive predictive value, NPV negative predictive value. HRP2 histidine-rich protein 2, pLDH lactate dehydrogenase, CI confidence interval