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Table 2 Comparison of rapid diagnostic test (RDTs) HRP2 (First Response®) and pLDH/HRP2 (Combo®) and microscopy with PCR

From: Diagnostic capacity, and predictive values of rapid diagnostic tests for accurate diagnosis of Plasmodium falciparum in febrile children in Asante-Akim, Ghana

Tests results GS: PCR (n = 246) Prevalence Sensitivity (95% CI) Specificity (95% CI) PPV (95% CI) NPV (95% CI)
Positive Negative
HRP2
 Positive 72 10 39.8 (33.7–46.3) 73.5 (63.6–81.9) 93.2 (87.9–96.7) 87.8 (79.6–93.0) 84.2 (79.2–88.1)
 Negative 26 138
Combo
 Positive 71 9 39.8 (33.7–46.3) 72.5 (62.5–81.0) 93.9 (88.8–97.2) 88.6 (80.5–93.8) 83.7 (78.8–87.7)
 Negative 27 139
Microscopy
 Positive 70 9 39.8 (33.7–46.3) 71.4 (61.4–80.1) 93.9 (88.8–97.2) 88.6 (80.3–93.7) 83.2 (78.4–87.2)
 Negative 28 139
  1. GS gold standard, PCR polymerase chain reaction, PPV positive predictive value, NPV negative predictive value. HRP2 histidine-rich protein 2, pLDH lactate dehydrogenase, CI confidence interval