Malaria Journal

Table 2 The IC₅₀ mean for 4a and 4c compounds and chloroquine

From: In vitro antiplasmodial activity, pharmacokinetic profiles and interference in isoprenoid pathway of 2-aniline-3-hydroxy-1.4-naphthoquinone derivatives

P. falciparum	4a		4c		Chloroquine
P. falciparum	Mean IC₅₀ (μg/ml)	Variance	Mean IC₅₀ (μg/ml)	Variance	Mean IC₅₀ (μg/ml)	Variance
3D7 strain	2.99^a	2.41–3.57	2.06^a	1.47–2.65	0.012^a	0.007–0.017
Dd2 strain	11.79^b	10.36–13.22	10.10^b	7.72–12.48	0.15^a	0.12–0.18

IC₅₀ (inhibitory concentration 50%); high activity^a (IC₅₀ ≤ 10 μg/ml); moderate activity^b (10 < IC₅₀ < 100 μg/ml) (Meneguetti et al. [31])

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ISSN: 1475-2875

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