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Fig. 3 | Malaria Journal

Fig. 3

From: The Plasmodium falciparum cytoplasmic translation apparatus: a promising therapeutic target not yet exploited by clinically approved anti-malarials

Fig. 3

Dose-dependent inhibition of S35 incorporation and PfIVT assays by negative control compounds. Dose-dependent inhibition, calculated as  % inhibition, of S35 incorporation (blue bars) and PfIVT assays (red bars) by negative control compounds: prokaryotic translation inhibitor and inhibitors of other (non-translation) cellular processes. Name of compound, mechanism of action, and molecular structure are displayed at top of each graph. Compounds were tested at 0.1-, 1-, 10-, and 100-fold the calculated EC50 calculated in in vivo growth inhibition assay, except where upper concentration was limited by solubility, indicated by *

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