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Fig. 4 | Malaria Journal

Fig. 4

From: The Plasmodium falciparum cytoplasmic translation apparatus: a promising therapeutic target not yet exploited by clinically approved anti-malarials

Fig. 4

Dose-dependent inhibition of S35 incorporation and PfIVT assays by antimalarial compounds. Dose-dependent inhibition, calculated as  % inhibition, of S35 incorporation (blue bars) and PfIVT assays (red bars) by pre-clinical and clinically-approved antimalarial compounds. Name of compound, mechanism of action (where definitively known), and molecular structure are displayed at top of each graph. Compounds were tested at 0.1-, 1-, 10-, and 100-fold the calculated EC50 calculated in in vivo growth inhibition assay, except where upper concentration was limited by solubility, indicated by *

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