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Table 3 Half-maximal effective concentrations (nM) determined in P. falciparum growth inhibition assay

From: The Plasmodium falciparum cytoplasmic translation apparatus: a promising therapeutic target not yet exploited by clinically approved anti-malarials

Test compounds 72H growth inhibition EC50 (nM) Antimalarials 72H growth inhibition EC50 (nM)
Bruceantin 4.2 MMV008270 2400
Verrucarin A 0.6 SJ733 60
Suramin 1819 M5717 (DDD107498) 1
Anisomycin 39 Quinine 370
Cycloheximide 0.6 Chloroquine 333
Homoharringtonine 6.8 Mefloquine 25
Lactimidomycin 22 Piperaquine 26
Nagilactone C 1310 Primaquine 1849
Puromycin 52 Monodesethyl amodiaquinea 61
Halofuginone  2 Lumefantrine 4
Thiostrepton 942 Dihydroartemisinin 3
Actinomycin D 10   
Tubercidin 168   
Thapsigargin 2900   
  1. a Active metabolite of amodiaquine
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