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Table 3 Mitochondrial gene variants in 73 children with severe malaria anaemia

From: Mitochondrial gene sequence variants in children with severe malaria anaemia with or without lactic acidosis: a case control study

  Any variant (full sequence) Any variant (oxphos genes) Non-synonymous (oxphos genes)
Number of variants found
 All subjects, n = 73 4770 2640 722
 High lactate, n = 36 2365 1315 373
 Normal lactate, n = 37 2405 1325 349
Median (IQR) variants/patient
 All subjects, n = 73 60 (42–91) 31 (24–51) 9 (7–13)
 High lactate, n = 36 57.5 (42–93) 31 (24–51) 9.5 (8.5–13)
 Normal lactate, n = 37 61 (45–90) 31 (27–50) 9 (7–12)
Average (SD) variants/1000 nucleotides
 All subjects, n = 73 3.97 (1.42) 3.19 (1.16) 0.87 (0.30)
 High lactate, n = 36 3.99 (1.53) 3.22 (1.26) 0.91 (0.33)
 Normal lactate, n = 37 3.95 (1.32) 3.16 (1.07) 0.83 (0.26)
  1. The number of variants, the median number (inter-quartile range, IQR) of variants per patient, and the average number of variants per patient per 1000 nucleotides is shown. The average number of non-synonymous variants per patient per 1000 nucleotides in genes of oxidative phosphorylation (oxphos) is not significantly different between the high lactate and normal lactate group, p = 0.08 (t-test)