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Table 3 Mitochondrial gene variants in 73 children with severe malaria anaemia

From: Mitochondrial gene sequence variants in children with severe malaria anaemia with or without lactic acidosis: a case control study

 

Any variant (full sequence)

Any variant (oxphos genes)

Non-synonymous (oxphos genes)

Number of variants found

 All subjects, n = 73

4770

2640

722

 High lactate, n = 36

2365

1315

373

 Normal lactate, n = 37

2405

1325

349

Median (IQR) variants/patient

 All subjects, n = 73

60 (42–91)

31 (24–51)

9 (7–13)

 High lactate, n = 36

57.5 (42–93)

31 (24–51)

9.5 (8.5–13)

 Normal lactate, n = 37

61 (45–90)

31 (27–50)

9 (7–12)

Average (SD) variants/1000 nucleotides

 All subjects, n = 73

3.97 (1.42)

3.19 (1.16)

0.87 (0.30)

 High lactate, n = 36

3.99 (1.53)

3.22 (1.26)

0.91 (0.33)

 Normal lactate, n = 37

3.95 (1.32)

3.16 (1.07)

0.83 (0.26)

  1. The number of variants, the median number (inter-quartile range, IQR) of variants per patient, and the average number of variants per patient per 1000 nucleotides is shown. The average number of non-synonymous variants per patient per 1000 nucleotides in genes of oxidative phosphorylation (oxphos) is not significantly different between the high lactate and normal lactate group, p = 0.08 (t-test)
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Malaria Journal

ISSN: 1475-2875

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