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Table 3 Genotypes of the SNPs and the association with presence/absence of antibodies

From: Host genetic polymorphisms and serological response against malaria in a selected population in Sri Lanka

Antibody type SNP Genotype With antibody, N (%) Without antibody, N (%) Model Comparison OR (95% CI) p-value
MSP1-19_Pv rs739718 (IL5) TT 165 (70.2) 70 (29.8) Co-dominant TT/CT 5.893 (1.117–31.101) 0.019
  CT 2 (28.6) 5 (71.4)     
MSP1-19_Pf rs6874639 (C5ORF56) AA 37 (39.4) 57 (60.6) Co-dominant AG/AA 2.054 (1.116–3.618) 0.12
  AG 60 (57.1) 45 (42.9) Co-dominant GG/AG 2.872 (1.339–6.159) 0.006
  GG 13 (31.7) 28 (68.3) Dominant AG/AA + GG 2.267 (1.364–3.816) 0.002
     Dominant GG/AA +AG 0.488 (0.239–0.997) 0.046
rs2706379 (C5ORF56) CC 38 (38.4) 61 (61.6) Co-dominant CT/CC 2.203 (1.253–3.873) 0.006
  CT 59 (57.8) 43 (42.2) Co-dominant CT/TT 2.639 (1.213–5.738) 0.013
  TT 13 (34.2) 25 (65.8) Dominant CC/CT + TT 0.588 (0.349–0.993) 0.046
     Dominant CT/CC + TT 2.314 (1.370–3.907) 0.002
  rs2706381 (C5ORF56) CC 38 (38.4) 61 (61.6) Co-dominant CT/CC 2.165 (1.230–3.811) 0.007
  CT 58 (57.4) 43 (42.6) Co-dominant CT/TT 2.698 (1.244–5.849) 0.011
  TT 13 (33.3) 26 (66.7) Dominant CT/CC + TT 2.301 (1.362–3.888) 0.002
rs2075820 (NOD1) AA 29 (64.4) 16 (35.6) Co-dominant AA/AG 2.595 (1.261–5.341) 0.009
   AG 44 (41.1) 63 (58.9) Co-dominant AA/GG 2.665 (1.259–5.642) 0.009
   GG 34 (40.5) 50 (59.5) Dominant AA/AG + GG 2.626 (1.337–5.158) 0.004
AMA1_Pv rs2075820 (NOD1) AA 42 (93.3) 3 (6.7) Co-dominant AA/AG 4.725 (1.354–16.49) 0.009
  AG 80 (74.8) 27 (25.2) Co-dominant AA/GG 5.60 (1.583–19.80) 0.004
  GG 60 (71.4) 24 (28.6) Dominant AA/AG + GG 5.10 (1.514–17.17) 0.004