| Annual burden of malariaa | Annual burden of malaria among cases that sought treatmentb | Impact of substandard and falsified anti-malarialsd | Impact of antimicrobial resistancee | ||||||
---|---|---|---|---|---|---|---|---|---|---|
Baseline | 95% CI | Baseline | 95% CI | Impact | % Diffc | p-value | Potential Impact | % Diffc | p-value | |
Avg. # cases | 3,528,304 | (3,527,862–3528,747) | 3,331,214 | (3,330,797–3,331,632) | 154 | 0% | 0.62 | − 841 | 0% | 0.01* |
Avg. # hospitalized | 176,744 | (175,095–178,393) | 176,744 | (175,095–178,393) | 13,919 | 8% | < 0.01* | 10,418 | 6% | < 0.01* |
Avg. # with NS | 10,924 | (10,720–11,128) | 5665 | (5531–5798) | 307 | 5% | 0.11 | 259 | 5% | < 0.01* |
Avg. # deaths | 29,481 | (29,089–29,874) | 12,893 | (12,668–13,117) | 1121 | 9% | < 0.01* | 884 | 7% | < 0.01* |
DALYs | 1,999,460 | (1,968,489–2,030,430) | 1,091,211 | (1,074,943–1,107,478) | 78,565 | 7% | < 0.01* | 63,040 | 6% | < 0.01* |
YLLs | 1,733,368 | (1,704,149–1,762,587) | 953,001 | (937,692–968,310) | 71,113 | 7% | < 0.01* | 56,681 | 6% | < 0.01* |
Economic impact | $613,510,000 | (605,555,098–621,465,371) | $402,945,000 | (394,989,859–410,900,132) | $31,009,000 | 8% | < 0.01* | $48,455,000 | 12% | < 0.01* |
Direct costs | $57,669,000 | (57,550,551–57,787,308) | $57,669,000 | (57,550,551–57,787,308) | $5,151,000 | 9% | < 0.01* | $15,539,000 | 27% | < 0.01* |
Facility costs | $32,550,000 | (32,469,063–32,631,682) | $32,550,000 | (32,469,063–32,631,682) | $2,857,000 | 9% | < 0.01* | $8,013,000 | 25% | < 0.01* |
Out-of-pocket costs | $25,119,000 | (25,081,489–25,155,626) | $25,119,000 | (25,081,489–25,155,626) | $2,294,000 | 9% | < 0.01* | $7,526,000 | 30% | < 0.01* |
Productivity losses | $555,841,000 | (547,706,922–563,975,688) | $345,276,000 | (340,893,439–349,658,692) | $25,859,000 | 7% | < 0.01* | $32,916,000 | 10% | < 0.01* |
Short-term | $88,273,000 | (86,720,283–89,825,161) | $140,798,000 | (129,970,519–151,626,292) | $8,083,000 | 6% | < 0.01* | $18,903,000 | 13% | < 0.01* |
Disability | $47,952,000 | (46,753,481–49,150,506) | $37,256,000 | (36,329,319–38,182,459) | $2,019,000 | 5% | < 0.01* | $1,725,000 | 6% | < 0.01* |
Death | $419,617,000 | (411,128,280–428,104,899) | $167,222,000 | (161,703,081–172,740,461) | $15,756,000 | 9% | < 0.01* | $12,287,000 | 7% | < 0.01* |