
AMA1 vaccine group

Control group


No primary outcome episodes before day 90 (n = 66)

No primary outcome episodes before day 90 (n = 22)


Predictor variable

Hazard ratio^{c}

P

Hazard ratio

P


log_{10} (IgG1 day 90)

1.17 [0.47, 2.93]

0.74

1.14 [0.65, 2.00]

0.66

log_{10} (IgG2 day 90)

0.92 [0.5, 1.70]

0.79

1.27 [0.43, 3.72]

0.66

log_{10} (IgG3 day 90)

1.89 [0.99, 3.61]

0.053

0.93 [0.35, 2.43]

0.87

log_{10} (IgG4 day 90)

1.06 [0.69, 1.63]

0.79

8.45 [0.61, 116.86]

0.11

log_{10} (cytophilic ratio^{d} day 90)

0.83 [0.40, 1.70]

0.61

1.05 [0.44, 2.53]

0.91

 ^{a}Gap time models with common regression coefficients using Firth’s penalized likelihood
 ^{b}Clinical malaria episode defined using the primary outcome definition, i.e., an episode of malaria with axillary temperature of ≥ 37.5 °C and asexual P. falciparum density of ≥ 2500 parasites/mm^{3} of blood
 ^{c}Hazard ratio and 95% confidence intervals for risk of multiple clinical malaria episodes after day 90
 ^{d}Cytophilic ratio is the sum of IgG1 and IgG2 titers divided by the sum of the IgG3 and IgG4 titers