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Table 4 Correlation between area under the curve parasitaemia during study days 90–240 and IgG subclass titers

From: Immunoglobulin G subclass and antibody avidity responses in Malian children immunized with Plasmodium falciparum apical membrane antigen 1 vaccine candidate FMP2.1/AS02A

  FMP2.1/AS02A vaccine group (n = 66) Control group (n = 22)
R P-value R P-value
IgG1 day 90 0.077 0.54 0.22 0.32
IgG2 day 90 0.026 0.84 0.11 0.64
IgG3 day 90 0.29 0.019 0.14 0.53
IgG4 day 90 − 0.057 0.66 0.22 0.33
IgG1 day 240 0.24 0.052 0.041 0.86
IgG2 day 240 0.13 0.28 0.11 0.62
IgG3 day 240 0.32 0.010 0.23 0.30
IgG4 day 240 − 0.16 0.20 0.24 0.28
  1. Italic values denote significant results. Volunteers who were treated for a clinical malaria episode before day 90 were excluded from this analysis. R, Spearman correlation coefficient