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Table 5 Correlation between area under the curve parasitaemia and IgG subclass titers in volunteers who received control vaccine

From: Immunoglobulin G subclass and antibody avidity responses in Malian children immunized with Plasmodium falciparum apical membrane antigen 1 vaccine candidate FMP2.1/AS02A

 

Control group (n = 29)

R

P-value

AUC days 0–90

 IgG1 day 90

0.48

0.009

 IgG2 day 90

0.60

0.0005

 IgG3 day 90

0.71

< 0.0001

 IgG4 day 90

0.57

0.001

 IgG1 day 240

0.25

0.19

 IgG2 day 240

0.39

0.036

 IgG3 day 240

0.45

0.015

 IgG4 day 240

0.35

0.059

AUC days 90–240

 IgG1 day 90

0.28

0.14

 IgG2 day 90

0.16

0.41

 IgG3 day 90

0.28

0.15

 IgG4 day 90

0.27

0.16

 IgG1 day 240

0.14

0.47

 IgG2 day 240

0.35

0.062

 IgG3 day 240

0.42

0.022

 IgG4 day 240

0.26

0.18

  1. Italic values denote significant results
  2. R Spearman correlation coefficient, AUC area under the curve
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Malaria Journal

ISSN: 1475-2875

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