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Table 5 Correlation between area under the curve parasitaemia and IgG subclass titers in volunteers who received control vaccine

From: Immunoglobulin G subclass and antibody avidity responses in Malian children immunized with Plasmodium falciparum apical membrane antigen 1 vaccine candidate FMP2.1/AS02A

  Control group (n = 29)
R P-value
AUC days 0–90
 IgG1 day 90 0.48 0.009
 IgG2 day 90 0.60 0.0005
 IgG3 day 90 0.71 < 0.0001
 IgG4 day 90 0.57 0.001
 IgG1 day 240 0.25 0.19
 IgG2 day 240 0.39 0.036
 IgG3 day 240 0.45 0.015
 IgG4 day 240 0.35 0.059
AUC days 90–240
 IgG1 day 90 0.28 0.14
 IgG2 day 90 0.16 0.41
 IgG3 day 90 0.28 0.15
 IgG4 day 90 0.27 0.16
 IgG1 day 240 0.14 0.47
 IgG2 day 240 0.35 0.062
 IgG3 day 240 0.42 0.022
 IgG4 day 240 0.26 0.18
  1. Italic values denote significant results
  2. R Spearman correlation coefficient, AUC area under the curve