MiRNA-146a polymorphism increases the odds of malaria in pregnancy

Malaria Journal

Table 1 Prevalence of P. falciparum infection (PCR) according to miRNA-146 genotype in pregnant women attending ANC

SNP rs2910164	Positive cases	Univariate analysis^a		Multivariate analysis^b
SNP rs2910164	% (Fraction)	OR (95% CI)	P	aOR (95% CI)	P
All	63.3 (322/509)
Wild type	55.5 (91/164)	1		1
Heterozygote	64.9 (159/245)	1.5 (1.0–2.3)	0.063	1.4 (0.9–2.1)	0.12
Homozygote	72.0 (72/100)	2.1 (1.2–3.7)	0.0089	2.3 (1.3–4.0)	0.0053
Het. or Hom.	67.0 (231/345)	1.6 (1.1–2.4)	0.014	1.6 (1.1–2.4)	0.023
Primigravidae	74.0 (94/127)
Wild type	60.0 (21/35)	1
Heterozygote	75.4 (46/61)	2.0 (0.8–5.5)	0.17	1.8 (0.7–4.7)	0.20
Homozygote	87.1 (27/31)	4.4 (1.2–21.0)	0.025	5.8 (1.6–26.0)	0.012
Het. or Hom.	79.3 (73/92)	2.5 (1.0–6.4)	0.040	2.5 (1.0–6.2)	0.040
Multigravidae	59.7 (288/382)
Wild type	54.3 (70/129)	1		1
Heterozygote	61.4 (113/184)	1.3 (0.8–2.2)	0.24	1.3 (0.8–2.1)	0.29
Homozygote	65.2 (45/69)	1.6 (0.8–3.0)	0.17	1.8 (0.9–3.4)	0.082
Het. or Hom.	62.5 (158/253)	1.4 (0.9–2.2)	0.12	1.4 (0.9–2.2)	0.14

Allele frequencies of SNP rs2910164 G > C were 0.47 (303/644) in infected and 0.38 (142/374) in non-infected women (P = 0.005)
OR odds ratio, aOR adjusted odds ratio
^aFisher’s exact test for independence, compared to reference (wild type)
^bLogistic regression model, including co-predictors age, PYR in urine or plasma and number of antenatal care visits. Effect of genotype on outcome variable was compared to reference (wild type)

ISSN: 1475-2875