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Table 2 Plasmodium falciparum (PCR) infection according to miRNA-146 genotype in placental blood of delivering primiparae

From: MiRNA-146a polymorphism increases the odds of malaria in pregnancy

SNP rs2910164

Positive cases

Univariate analysisa

Multivariate analysisb

% (Fraction)

OR (95% CI)

P

aOR (95% CI)

P

Primiparae

64.9 (192/296)

    

 Wild type

60.4 (55/91)

1

 

1

 

 Heterozygote

60.8 (87/143)

1.0 (0.6–1.8)

1.0

1.4 (0.7–2.9)

0.38

 Homozygote

80.6 (50/62)

2.7 (1.2–6.4)

0.013

5.9 (2.1–18.0)

0.0011

 Het. or Hom.

66.8 (137/205)

1.3 (0.8–2.3)

0.29

2.1 (1.0–4.2)

0.038

  1. Allele frequencies of SNP rs2910164 G > C were 0.49 (187/384) in infected (PCR) and 0.38 (80/208) in non-infected women (P = 0.02)
  2. OR odds ratio, aOR adjusted odds ratio
  3. aFisher’s exact test for independence, compared to reference (wild type)
  4. bLogistic regression model, including co-predictors age, season, PYR in urine or plasma and number of antenatal care visits. Effect of genotype on outcome variable was compared to reference (wild type)
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Malaria Journal

ISSN: 1475-2875

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