MiRNA-146a polymorphism increases the odds of malaria in pregnancy

Malaria Journal

Table 3 Past or present placental malaria (PCR, microscopy, haemozoin) according to miRNA-146 genotype in delivering primiparae

SNP rs2910164	Positive cases	Univariate analysis^a		Multivariate analysis^b
SNP rs2910164	% (Fraction)	OR (95% CI)	P	aOR (95% CI)	P
Primiparae	67.9 (201/296)
Wild type	61.5 (56/91)	1		1
Heterozygote	66.4 (95/143)	1.2 (0.7–2.2)	0.48	1.6 (0.8–3.5)	0.21
Homozygote	80.6 (50/62)	2.6 (1.2–6.1)	0.013	5.9 (2.1–19.0)	0.0013
Het. or Hom.	72.2 (145/205)	1.5 (0.9–2.6)	0.14	2.3 (1.1–4.7)	0.020

OR odds ratio, aOR adjusted odds ratio
^aFisher’s exact test for independence, compared to reference (wild type)
^bLogistic regression model, including co-predictors age, season, PYR in urine or plasma and number of antenatal care visits. Effect of genotype on outcome variable was compared to reference (wild type)

ISSN: 1475-2875