The impact of early life exposure to Plasmodium falciparum on the development of naturally acquired immunity to malaria in young Malawian children

Table 4 Association between number of malaria episodes and antibody level in 18 months old children

Antigen tested/parasite isolate	Unadjusted coefficient (95% CI)	p value^a	Adjusted coefficient (95% CI)	p value^b
MSP1 19 kD^c	1.85 (1.43, 2.41)	< 0.0001	1.83 (1.41, 2.37)	< 0.0001
MSP2^d	1.28 (1.00, 1.63)	0.047	1.26 (0.99, 1.61)	0.057
EBA175^e	0.92 (0.75, 1.11)	0.399	0.91 (0.76, 1.10)	0.378
Rh2A9^f	1.14 (0.98, 1.33)	0.074	1.14 (0.98, 1.33)	0.082
Schizont	1.52 (1.21, 1.91)	< 0.0001	1.50 (1.19, 1.87)	< 0.0001
E8B^g	1.06 (0.75, 1.50)	0.719	1.03 (0.73, 1.46)	0.826
R29^h	1.33 (0.79, 2.24)	0.267	1.39 (0.81, 2.40)	0.222
3D7^h	1.16 (0.79, 1.72)	0.434	1.13 (0.77, 1.67)	0.508

Significant p value in italic format
^ap-value derived from linear regression of antibody levels and reported as coefficient and 95% confidence intervals (CI)
^bp-value calculated using multivariate linear regression of antibody levels reporting coefficient and 95% confidence intervals (CI) while adjusting for duration of gestation, HIV infection, gender of the child, maternal anaemia
^cMerozoite surface protein 1
^dMerozoite surface protein 2
^eErythrocyte binding antigen 175
^fReticulocyte binding protein homologue 2A
^gVariant surface antigen antibody responses

ISSN: 1475-2875