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Table 4 Association between number of malaria episodes and antibody level in 18 months old children

From: The impact of early life exposure to Plasmodium falciparum on the development of naturally acquired immunity to malaria in young Malawian children

Antigen tested/parasite isolate Unadjusted coefficient (95% CI) p valuea Adjusted coefficient (95% CI) p valueb
MSP1 19 kDc 1.85 (1.43, 2.41) <0.0001 1.83 (1.41, 2.37) <0.0001
MSP2d 1.28 (1.00, 1.63) 0.047 1.26 (0.99, 1.61) 0.057
EBA175e 0.92 (0.75, 1.11) 0.399 0.91 (0.76, 1.10) 0.378
Rh2A9f 1.14 (0.98, 1.33) 0.074 1.14 (0.98, 1.33) 0.082
Schizont 1.52 (1.21, 1.91) <0.0001 1.50 (1.19, 1.87) <0.0001
E8Bg 1.06 (0.75, 1.50) 0.719 1.03 (0.73, 1.46) 0.826
R29h 1.33 (0.79, 2.24) 0.267 1.39 (0.81, 2.40) 0.222
3D7h 1.16 (0.79, 1.72) 0.434 1.13 (0.77, 1.67) 0.508
  1. Significant p value in italic format
  2. ap-value derived from linear regression of antibody levels and reported as coefficient and 95% confidence intervals (CI)
  3. bp-value calculated using multivariate linear regression of antibody levels reporting coefficient and 95% confidence intervals (CI) while adjusting for duration of gestation, HIV infection, gender of the child, maternal anaemia
  4. cMerozoite surface protein 1
  5. dMerozoite surface protein 2
  6. eErythrocyte binding antigen 175
  7. fReticulocyte binding protein homologue 2A
  8. gVariant surface antigen antibody responses