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Table 3 IC50 values of newly synthesized inhibitors on PfGluPho, PvG6PD, and hG6PD

From: Glucose 6-phosphate dehydrogenase 6-phosphogluconolactonase: characterization of the Plasmodium vivax enzyme and inhibitor studies

  PfGluPho [µM] PvG6PD [µM] hG6PD [µM]
2 (vz1731) 11.7 ± 9.9 2.1 ± 0.1 91.7 ± 35.0
4 (vz1732) 0.9 ± 0.2 0.2 ± 0.0 34.7 ± 21.0
8 (vz0882) 18.1 ± 10.4 12.8 ± 7.8 N. d.
10 (vz1204) N. d. 23.5 ± 3.7 > 100
13 (vz0288) 29.6 ± 23.2 23.3 ± 7.8 > 100
18 (vz0909) 23.6 ± 14.3 9.1 ± 2.8 26.0 ± 1.8
19 (vz0914) 8.4 ± 8.4 5.6 ± 0.6 29.6 ± 5.0
20 (vz0005) > 100 > 100 > 100
21 (vz0527) 1.7 ± 0.3 0.2 ± 0.1 8.3 ± 2.7
  1. N. d. not determined due to low solubility/reproducibility
  2. Values are represented as mean ± SD of at least two independent determinations using different batches of enzyme, each including at least two independent measurements. For hG6PD, only one enzyme batch was used