Table 3 IC50 values of newly synthesized inhibitors on PfGluPho, PvG6PD, and hG6PD
|  | PfGluPho [µM] | PvG6PD [µM] | hG6PD [µM] |
|---|---|---|---|
2 (vz1731) | 11.7 ± 9.9 | 2.1 ± 0.1 | 91.7 ± 35.0 |
4 (vz1732) | 0.9 ± 0.2 | 0.2 ± 0.0 | 34.7 ± 21.0 |
8 (vz0882) | 18.1 ± 10.4 | 12.8 ± 7.8 | N. d. |
10 (vz1204) | N. d. | 23.5 ± 3.7 | > 100 |
13 (vz0288) | 29.6 ± 23.2 | 23.3 ± 7.8 | > 100 |
18 (vz0909) | 23.6 ± 14.3 | 9.1 ± 2.8 | 26.0 ± 1.8 |
19 (vz0914) | 8.4 ± 8.4 | 5.6 ± 0.6 | 29.6 ± 5.0 |
20 (vz0005) | > 100 | > 100 | > 100 |
21 (vz0527) | 1.7 ± 0.3 | 0.2 ± 0.1 | 8.3 ± 2.7 |