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Table 2 Distribution of the G6PD variants by gender and genotype in samples collected from Cambodia, Lao PDR, Myanmar, Thailand and Vietnam

From: Molecular characterization and mapping of glucose-6-phosphate dehydrogenase (G6PD) mutations in the Greater Mekong Subregion

Country Gender Normala Genotype G6PD variants % Carriers Cumulative allelic frequency
Total Canton Chinese-4 Chinese-5 Coimbra Kaiping Mahidol Med Union Viangchan
Cambodiab Males 1756 Hemizygote 406 4 NI 2 3 NI 8 3 3 383 18.8 18.8
Females 0 Homozygote NI NI NI NI NI NI NI NI NI NI NI NI
Heterozygote NI NI NI NI NI NI NI NI NI NI NI NI
Lao PDRb Males 1123 Hemizygote 88 1 5 NI NI 3 2 NI 6 71 7.3 7.3
Females 1709 Homozygote 9 NI NI NI 9 0.5 1.7c
Heterozygote 42 1 NI NI 1 2 NI 3 35 2.4
Thailand Males 165 Hemizygote 13 NI NI NI NI NI 6 NI NI 7 7.3 7.3
Females 188 Homozygote 3 NI NI NI NI NI 2 NI NI 1 1.3 10.5
Heterozygote 43 NI NI NI NI 21 NI NI 22 18.4
Myanmar Males 1222 Hemizygote 202 6 5 NI NI 2 188 NI 1 14.2 14.2
Females 998 Homozygote 34 1 NI NI 33 NI 2.6 13.5
Heterozygoted 289 6 NI NI 279 NI 4 21.9
Vietnam Males 856 Hemizygote 52 NI NI NI NI NI 2 50 5.7 5.7
Females 949 Homozygote 13 NI NI NI NI NI 13 1.3 3.5c
Heterozygote 45 NI NI NI NI NI 2 43 4.5
Total   8966   1239 18 11 2 3 6 541 3 16 639 12.1  
  1. NI indicates that a mutation was not investigated; a dash indicates that a mutation was not found
  2. aEither by genotype as wild-type by PCR–RFLP or by phenotype as normal by FST
  3. b225 samples in Cambodia and 61 samples in Lao PDR are reported here with genotypes but are not represented in the maps because of missing GPS coordinates
  4. cOnly samples with deficient and intermediate phenotype were genotyped; therefore the allelic frequency in females is underestimated
  5. dThis includes five women genotyped as double heterozygous for Canton-Mahidol and two women genotyped double heterozygote for Mahidol-Viangchan. They were counted once in each mutation column