Molecular characterization and mapping of glucose-6-phosphate dehydrogenase (G6PD) mutations in the Greater Mekong Subregion

Table 2 Distribution of the G6PD variants by gender and genotype in samples collected from Cambodia, Lao PDR, Myanmar, Thailand and Vietnam

Country	Gender	Normal^a	Genotype	G6PD variants										% Carriers	Cumulative allelic frequency
Country	Gender	Normal^a	Genotype	Total	Canton	Chinese-4	Chinese-5	Coimbra	Kaiping	Mahidol	Med	Union	Viangchan	% Carriers	Cumulative allelic frequency
Cambodia^b	Males	1756	Hemizygote	406	4	NI	2	3	NI	8	3	3	383	18.8	18.8
	Females	0	Homozygote	NI	NI	NI	NI	NI	NI	NI	NI	NI	NI	NI	NI
	Females	0	Heterozygote	NI	NI	NI	NI	NI	NI	NI	NI	NI	NI	NI	NI
Lao PDR^b	Males	1123	Hemizygote	88	1	5	NI	NI	3	2	NI	6	71	7.3	7.3
	Females	1709	Homozygote	9	–	–	NI	NI	–	–	NI	–	9	0.5	1.7^c
	Females	1709	Heterozygote	42	–	1	NI	NI	1	2	NI	3	35	2.4	1.7^c
Thailand	Males	165	Hemizygote	13	NI	NI	NI	NI	NI	6	NI	NI	7	7.3	7.3
	Females	188	Homozygote	3	NI	NI	NI	NI	NI	2	NI	NI	1	1.3	10.5
	Females	188	Heterozygote	43	–	NI	NI	NI	NI	21	NI	NI	22	18.4	10.5
Myanmar	Males	1222	Hemizygote	202	6	5	NI	NI	2	188	NI	–	1	14.2	14.2
	Females	998	Homozygote	34	1	–	NI	NI	–	33	NI	–	–	2.6	13.5
	Females	998	Heterozygote^d	289	6	–	NI	NI	–	279	NI	–	4	21.9	13.5
Vietnam	Males	856	Hemizygote	52	–	NI	NI	NI	–	NI	NI	2	50	5.7	5.7
	Females	949	Homozygote	13	–	NI	NI	NI	–	NI	NI	–	13	1.3	3.5^c
	Females	949	Heterozygote	45	–	NI	NI	NI	–	NI	NI	2	43	4.5	3.5^c
Total		8966		1239	18	11	2	3	6	541	3	16	639	12.1

NI indicates that a mutation was not investigated; a dash indicates that a mutation was not found
^aEither by genotype as wild-type by PCR–RFLP or by phenotype as normal by FST
^b225 samples in Cambodia and 61 samples in Lao PDR are reported here with genotypes but are not represented in the maps because of missing GPS coordinates
^cOnly samples with deficient and intermediate phenotype were genotyped; therefore the allelic frequency in females is underestimated
^dThis includes five women genotyped as double heterozygous for Canton-Mahidol and two women genotyped double heterozygote for Mahidol-Viangchan. They were counted once in each mutation column

ISSN: 1475-2875