Table 2 Rates of clinical malaria from a passively followed cohort of children under 5 years of age

January–July 2013

Overall incidence

0.12 (0.06–0.22) [124/1057]

–

–

Lower resistance (mortality equal to or above median value of 95.3%)

0.05 (0.02–0.13) [28/530]

1

1

Higher resistance (mortality below median value of 95.3%)

0.18 (0.09–0.39) [96/527]

3.45 (1.17–10.20)

p = 0.027

2.48 (0.88–7.00)

p = 0.082

Effect per 10% reduction in bioassay mortality

–

1.46 (0.84–2.54)

p = 0.170

1.11 (0.68–1.82)

p = 0.667

August–December 2013

Overall incidence

0.31 (0.19–0.49) [240/778]

–

–

Lower resistance (mortality equal to or above median value of 93.9%)

0.42 (0.22–0.80) [158/373]

1

1

Higher resistance (mortality below median value of 93.9%)

0.20 (0.11–0.39) [82/405]

0.48 (0.21–1.11)

p = 0.083

0.60 (0.26–1.37)

p = 0.214

Effect per 10% reduction in bioassay mortality

–

0.45 (0.16–1.33)

p = 0.143

0.46 (0.14–1.58)

p = 0.208

January–December 2014

Overall incidence

0.23 (0.13–0.41) [420/1804]

–

–

Lower resistance (mortality equal to or above median value of 47.2%)

0.09 (0.04–0.25) [86/907]

1

1

Higher resistance (mortality below median value of 47.2%)

0.37 (0.20–0.70) [334/897]

3.93 (1.34–11.51) p = 0.015

2.46 (0.89–6.78)

p = 0.080

Effect per 10% reduction in bioassay mortality

–

1.61 (1.21–2.13) p = 0.002

1.28 (0.91–1.79)

p = 0.144

January 2013–December 2014 (all time periods combined)

Overall incidence

0.22 (0.14–0.34) [784/3639]

–

–

Lower resistance (mortality equal to or above median value of 47.2%)

0.20 (0.13–0.31) [270/1378]

1

1

Higher resistance (mortality below median value of 91.3%)

0.23 (0.13–0.40) [514/2261]

1.11 (0.52–2.35)

p = 0.777

0.89 (0.42–1.86)

p = 0.738

Effect per 10% reduction in bioassay mortality

–

1.50 (1.14–1.97)

p = 0.005

1.17 (0.90–1.53)

p = 0.239