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Fig. 2 | Malaria Journal

Fig. 2

From: Formation primaquine-5,6-orthoquinone, the putative active and toxic metabolite of primaquine via direct oxidation in human erythrocytes

Fig. 2

LC/MS chromatogram showing orthoquinone and PQ after incubation of human RBCs with PQ containing a mixture of 12C-PQ and 13C-PQ (13C at 6 quinoline core carbons). The peak at retention time 4.65 min corresponds to the orthoquinone standard, while the peak at 14 min corresponds to PQ. The mass spectrometric fragmentation at right shows the expected +6 mu

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