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Fig. 4 | Malaria Journal

Fig. 4

From: Formation primaquine-5,6-orthoquinone, the putative active and toxic metabolite of primaquine via direct oxidation in human erythrocytes

Fig. 4

The concentration-time profile of primaquine 5,6-orthoquinone formed from primaquine incubation in human RBC. Whole RBC treatment involved the precipitation and lysing of the cells followed by recovery of the analytes. Alternatively, the incubation mixture was separated into the cellular pellets and the supernatants prior to analyte recovery and analysis

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