Fig. 11

Homology models of PfArgRS and HsArgRS and prediction of potential ligand binding sites. The catalytic domain of the models is shown in cyan, the anticodon binding domain (ABD) in grey and the N-terminal domains of PfArgRS and HsArgRS are shown in a light orange colour. The HIGH and KMSKS motifs highly conserved in Class I are shown in red and yellow respectively. Known druggable sites are shown by the red dotted ellipses while the predicted site in PfArgRS by FTMap is shown in purple dotted ellipses. a PfArgRS homology model. b Insert – zoomed view of the predicted druggable site in PfArgRS with the residues interacting with probes represented as magenta sticks. c HsArgRS homology model. No probable druggable sites were predicted in human homologue. d Motif 4 and 6 logos showing conservation of residues in this family and PfArgRS residues interacting with probes at the predicted site