Fig. 12From: Aminoacyl tRNA synthetases as malarial drug targets: a comparative bioinformatics studyHomology models of PfMetRS and HsMetRS and prediction of potential ligand binding sites. The catalytic domain of the models is shown in cyan and the anticodon binding domain (ABD) in grey. The HIGH and KMSKS motifs are shown in red and yellow respectively. a PfMetRS homology model. Known druggable sites are shown by the red dotted ellipses while the predicted site in PfMetRS by FTMap is shown in purple dotted ellipses. b Insert—zoomed view of the predicted druggable pocket in PfMetRS showing stick representation (magenta) of residues interacting with probes at this site. The predicted site is located at the catalytic domain c HsMetRS homology model. HsMetRS had no probable druggable sites predicted by FTMap. d Motif 5, 9 and 20 logos showing conservation of residues in this family and PfMetRS residues interacting with probes predicted siteBack to article page