Fig. 13

Build homology models of ProRS and prediction of potential ligand binding sites. The catalytic domain is shown in cyan, anticodon binding domain in grey and the C-terminal zinc-binding like domain is shown in light pink colour. Motif 2 located at the catalytic domain is shown in yellow. Known druggable sites are shown by the red dotted ellipses while other predicted sites by FTMap are shown in purple dotted ellipses. a The homology model of PfProRS. b Insert—zoomed view of the predicted site in PfProRS showing residues interacting with probes at this site as magenta sticks. These probes were interacting with residues—Tyr746, Thr397, Phe262, Arg401 and Lys394. c The homology model of HsLysRS showing a probable druggable site with residues Thr1164, Phe1161, Thr1277, Leu1162, Thr1276 and Arg1278 interacting with probes. d Motif 1 and 11 logos showing conservation of residues in these motifs and PfProRS residues interacting with probes at the predicted site