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Fig. 7 | Malaria Journal

Fig. 7

From: Aminoacyl tRNA synthetases as malarial drug targets: a comparative bioinformatics study

Fig. 7

a TyrRS family phylogenetic tree. Maximum Likelihood method was used to infer evolutionary history using Le_Gascuel_2008 model at 95% site coverage [150]. Phylogenetic tree calculations were done using MEGA7 [102]. The tree that had the highest log likelihood (-2978.09) is shown. Initial tree(s) for the heuristic search were obtained by using BioNJ and Neighbour-Join algorithms to a matrix of pairwise distances calculated using a JTT model, and then selecting the topology with higher log likelihood value. A Gamma distribution was used to calculate evolutionary rate differences among sites (5 categories (+G, parameter = 0.4355)). Nine amino acid sequences were used for this analysis. There were 343 positions after the calculations. b TyrRS pairwise sequence calculations. The sequence identity values of the sequences in the TyrRS family is shown. The heatmap shows the identity scores as a colour-coded matrix for every aaRS sequence versus every aaRS sequence in this family. Conservation increases from blue to red in the heat map

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