Table 2 Highly conserved motifs in Class II aaRS
From: Aminoacyl tRNA synthetases as malarial drug targets: a comparative bioinformatics study
| Â | Motif 1 | Motif 2 | Motif 19 | Motif 20 |
|---|---|---|---|---|
PfAlaRS | 620–640 | – | – | 942–962 |
HsAlaRS | 236–256 | – | – | 23–43 |
PfAsnRS | 574–594 | 369–389 | – | 343–363 |
HsAsnRS | 512–532 | 313–333 | 249–289 | – |
PfAspRS | 590–610 | 382–402 | 317–357 | 360–380 |
HsAspRS | 465–485 | 264–284 | 199–239 | 242–262 |
PfGlyRS | – | 469–489 | – | 173–193 |
HsGlyRS | – | 322–342 | – | 130–150 |
PfHisRS | 918–938 | 688–708 | – | 658–678 |
HsHisRS | 378–398 | 148–168 | – | 118–138 |
PfLysRS | 549–569 | 321–341 | 254–294 | 362–382 |
HsLysRS | 543–563 | 314–334 | 247–287 | – |
PfPheRS | 313–333 | – | – | 110–130 |
HsPheRS | 308–328 | – | – | – |
PfProRS | – | 463–483 | – | – |
HsProRS | – | 1225–1245 | – | – |
PfSerRS | – | – | – | 202–222 |
HsSerRS | – | – | – | 192–212 |
PfThrRS | 653–673 | – | – | 358–378 |
HsThrRS | 444–464 | – | – | 151–171 |