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Table 2 Highly conserved motifs in Class II aaRS

From: Aminoacyl tRNA synthetases as malarial drug targets: a comparative bioinformatics study

  Motif 1 Motif 2 Motif 19 Motif 20
PfAlaRS 620–640 942–962
HsAlaRS 236–256 23–43
PfAsnRS 574–594 369–389 343–363
HsAsnRS 512–532 313–333 249–289
PfAspRS 590–610 382–402 317–357 360–380
HsAspRS 465–485 264–284 199–239 242–262
PfGlyRS 469–489 173–193
HsGlyRS 322–342 130–150
PfHisRS 918–938 688–708 658–678
HsHisRS 378–398 148–168 118–138
PfLysRS 549–569 321–341 254–294 362–382
HsLysRS 543–563 314–334 247–287
PfPheRS 313–333 110–130
HsPheRS 308–328
PfProRS 463–483
HsProRS 1225–1245
PfSerRS 202–222
HsSerRS 192–212
PfThrRS 653–673 358–378
HsThrRS 444–464 151–171
  1. Motif 1, 2, 19 and 20 in Class II P. falciparum aaRS and the human homologues. Motif positions in the sequences are indicated and dashes are used where the motif is not present