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Table 3 Logistic regression model showing the effect of baseline characteristics on the PCR-uncorrected ACPR rate

From: Relationship between weight status and anti-malarial drug efficacy and safety in children in Mali

 

Estimate

Std. error

z value

OR (95% CI)

p-value

Artesunate + amodiaquine

 Intercept

− 0.62

2.46

− 0.25

0.54 (0.004, 83.21)

0.80

 Underweight

− 0.18

1.19

− 0.15

0.84 (0.11, 17.69)

0.88

 Overweight

− 1.54

0.66

− 2.34

0.21 (0.06, 0.76)

0.02

 Parasitaemia

1.06e−07

1.15e−05

0.009

1 (0.99, 1)

0.99

 ALAT

− 0.02

0.01

− 1.21

0.98 (0.95, 1.00)

0.22

 ASAT

− 0.002

0.01

− 0.22

0.99 (0.98, 1.02)

0.82

 Creatinine

0.75

1.12

0.67

2.12 (0.59, 50.83)

0.50

 Hb level

0.27

0.21

1.29

1.31 (0.87, 2.01)

0.19

Artesunate + sulfadoxine–pyrimethamine

 Intercept

0.75

3.04

0.25

2.12 (0.005, 1.00e+03)

0.80

 Underweight

− 0.33

1.29

− 0.26

0.72 (0.07, 16.8)

0.79

 Overweight

− 0.19

1.02

0.19

1.22 (0.17, 11.2)

0.85

 Parasitaemia

− 1.39e−05

1.65e−05

− 0.84

0.99 (0.99, 1)

0.40

 ALAT

0.03

0.05

0.63

1.03 (0.94, 1.16)

0.53

 ASAT

− 0.003

0.03

− 0.08

1 (0.95, 1.07)

0.53

 Creatinine

5.91

3.22

1.84

369.65 (1.39, 4.8e+05)

0.07

 Hb level

− 0.16

0.29

− 0.56

0.99 (0.47, 1.49)

0.58

Artesunate in monotherapy

 Intercept

− 3.56

1.97

− 1.80

0.03 (0.0005, 1.18)

0.07

 Underweight

1.14

0.94

1.21

3.11 (0.56, 25.64)

0.23

 Overweight

0.46

0.69

0.67

1.58 (0.42, 6.44)

0.50

 Parasitaemia

3.73e−06

9.42e−06

0.39

1 (0.99, 1)

0.69

 ALAT

− 0.046

0.02

− 2.26

0.95 (0.91, 0.99)

0.02

 ASAT

0.003

0.008

1.03

1.01 (0.98, 1.02)

0.31

 Creatinine

3.39

1.83

1.85

29.77 (1.71, 2088.11)

0.06

 Hb level

0.24

0.17

1.49

1.27 (0.93, 1.77)

0.14

  1. ALAT: alanine aminotransferase; ASAT: aspartate aminotransferase; Hb: haemoglobin