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Table 2 Non-synonymous K13-mutations associated with delayed ART parasite clearance

From: K13-propeller gene polymorphisms in Plasmodium falciparum parasite population in malaria affected countries: a systematic review of prevalence and risk factors

S/n

K13-mutation

No. of P. falciparum parasite infections

Region/country

References

1.

F446I

98

Malaysia, South China, India, Myanmar

[12, 13, 19, 30, 31, 36]

2.

P574L

61

Southeast Asia, Africa, Rwanda

[12, 14, 21, 30,31,32]

3.

N458Y

22

Asia,

[11, 12, 19]

4.

M476I

30

Myanmar

[28, 30]

5.

A675V

28

Rwanda, Uganda, Myanmar

[21, 32, 39]

6.

N537D

31

Myanmar

[29]

7.

R561H

12

Myanmar, India

[12, 29, 59]

8.

G538V

06

Asia

[11]

9.

I543T

05

Asia

[11]

10.

Q613E

01

Dakar, Senegal

[22]

11.

P553L

07

Southeast Asia

[12, 14, 17, 26, 29, 53, 54, 57]

12.

P667T

05

Myanmar

[28]

13.

C469F

11

Myanmar

[29]

14.

F673I

01

Myanmar

[29]

15.

K189T

49

Senegal, Uganda

[11, 19, 20, 22]

16.

E252Q

17

Southeast Asia

[11, 19, 30]