K13-propeller gene polymorphisms in Plasmodium falciparum parasite population in malaria affected countries: a systematic review of prevalence and risk factors

Table 3 Nucleotide changes for commonly reported non-validated K13-mutations

S/n	Codon position	Nucleotide change	Region/country	Article/study reporting the mutation
1.	A578S	GCT → TCT	China, Kenya, Grande Comore Island, Equatorial Guinea, Togo, Uganda, southeast Asia	[26, 31] [5, 23] [27, 64] [20, 25]
2.	S522C	AGT → AGG	Togo, Uganda, southeast Asia	[25, 68] [12]
3.	N554L	AAT → AGT AAT → CAT	Kenya, Senegal	[22, 23]
4.	P574L	CCT → CTT	Myanmar, Rwanda, Thailand	[28, 32] [5, 37] [12, 23]
5.	A569S	GCA → ACA	Sub-Saharan Africa	[5, 23]
6.	V637I	GTT → ATT	Equatorial Guinea, Senegal	[26, 27] [22]
7.	G449A	GGT → GCT	Sub-Saharan Africa Myanmar, Cambodia	[15, 26] [1]
8.	N537I	AAT → ATT	Cambodia, Myanmar	[1, 12, 15]
9.	D648H	GAT → AAT	China, Africa	[31, 32]
10.	A557S	GCA → TCA	Sub-Saharan Africa	[5, 26]
11.	A626S	GCA → TCA GCA → ACA	Rwanda China	[31, 32]
12.	M476V	ATG → ATA	China, Africa, Myanmar	[15, 29, 31]
13.	N458Y	AAT → TAT	Cambodia, Thailand	[1, 12, 37]
14.	G533C	GGT → TGT	Uganda, Cambodia	[1, 68]
15.	A617T	G → A	Sub-Saharan Africa	[20, 26]
16.	R575T	AGA → AAA	Thailand, Myanmar, Ghana, China	[15, 33, 37]
17.	V589I	GTC → ATC	China, Africa, SEA	[5, 12, 31]
18.	E556D	GAA → AAA	Equatorial Guinea, South China, Thailand, Africa	[27, 31, 36, 37]
19.	D584N	GAT → GAA GAT → GTT	Grande Comore Island Ghana, China	[64] [33]
20.	A675V	GCT → GTT	Rwanda, Uganda, Myanmar	[15, 32, 39]

ISSN: 1475-2875