In vivo compartmental kinetics of Plasmodium falciparum histidine-rich protein II in the blood of humans and in BALB/c mice infected with a transgenic Plasmodium berghei parasite expressing histidine-rich protein II

Table 1 Quantification of RBCs positive for PfHRP2 but parasite negative in patients post-treatment for P. falciparum

Pt	Days post-treatment	Pfs25 copies/µL	RBC PfHRP2 (ng/mL)	Plasma PfHRP2 (ng/mL)	PfHRP2 RBC/Plasma ratio	% of iRBCs/total RBCs	% of PfHRP2 positive/total RBCs	Treatment
1	1	482,693	183,208	7116	26	11.6	Not done	Doxycycline, quinidine, artemether–lumefantrine
	2	2759	160,177	2289	70	< 0.5	3.7
	2.4	502	74,179	2272	33	0	5.2
	3	150	79,094	1214	65	0	6.5
	12	0	25,830	397	65	0	3.5
2	1	11,945	37,948	1999	19	1.2	Not done	Atovaquone–proguanil
2	3	516	4535	92	49	< 0.5	0.38	Atovaquone–proguanil
3	0	50,398	43,787	2113	21	2.8	0	Artemether–lumefantrine
	1	498	16,370	1529	11	0	1.2
	2	158	8821	847	10	0	0.63
4	1	14,289	21,140	85	248	1.0	Not done	Quinine, atovaquone–proguanil
4	6	0	43	21	2	0	1.7	Quinine, atovaquone–proguanil
5	0	24	277	11	25	< 0.5	Not done	Atovaquone–proguanil
	1	12,863	38,051	3	12,683	1.1	Not done
	3	101	2759	129	21	0	0
6	2	3141	12,372	181	68	< 0.5	0.13	Atovaquone–proguanil

ISSN: 1475-2875