Fig. 4

Key purine metabolites under hypoxanthine-rich (hxan-R) and -deprived (hxan-D) conditions. a Adenosine, b inosine, c hypoxanthine, and d inosine monophosphate (IMP) levels from parasite-infected red blood cells under the two conditions. At the first two time points of hypoxanthine deprivation, each metabolite was higher than its value under the hypoxanthine-rich condition. During the second day of infection under the hypoxanthine-deprived condition, inosine and hypoxanthine levels were substantially lower than their values under the hypoxanthine-rich condition. To allow comparison of a metabolite between the two conditions, the value of a given metabolite was normalized by its initial value at time 0 h. The error bars show the standard deviations of measurements from four technical replicates