Fig. 6

Gene set enrichment analysis of stress response pathways (SRPs) in Plasmodium falciparum. Results for transcriptomic data obtained under a hypoxanthine and b isoleucine deprivation. The figure shows gene ontologies associated with the SRPs of P. falciparum. Here each circle represents a gene ontology associated with the SRPs, where the size of an ontology circle is proportional to the number of genes in it. A black line drawn from a colored circle to the SRP indicates that this gene set directly influences the SRP. Similar gene sets are clustered together and grey lines are used to indicate interaction between them. The cluster named ‘interaction with host’ contains proteins associated with Maurer’s cleft and parasitic protein export. ‘RBC adhesion’ contains P. falciparum red blood cell (RBC) membrane protein 1 (PfEMP1) and associated proteins, which are inserted in the RBC plasma membrane. The colour of a circle indicates whether or not a given gene set was enriched (dark red, p < 0.01; light red, 0.01 ≤ p < 0.05; yellow, 0.05 ≤ p < 0.10; green, p ≥ 0.10)