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Fig. 7 | Malaria Journal

Fig. 7

From: Short-term metabolic adjustments in Plasmodium falciparum counter hypoxanthine deprivation at the expense of long-term viability

Fig. 7

Plasmodium falciparum metabolic enzymes involved in the hypoxanthine salvage and recycling process. a Hypoxanthine phosphoribosyltransferase (HXPRT) catalyzes the formation of inosine monophosphate (IMP) from hypoxanthine. b IMP dehydrogenase (IMPD) catalyzes the formation of xanthine monophosphate (XMP) from IMP. c Adenylosuccinate synthase (ADSS) catalyzes the formation of adenylosuccinic acid from IMP. d Compensatory mechanism involved in maintenance of the hypoxanthine pool under deprivation conditions. e Purine nucleoside phosphorylase (PNP) catalyzes the formation of hypoxanthine from inosine (INS). In ac and e, the ordinate shows the reaction rate of the metabolic enzyme. The error bars show the standard deviations of 50 simulations computed after adding random Gaussian noise with a mean of zero and a standard deviation of 5% to the transcriptomic data obtained under hypoxanthine-rich and hypoxanthine-deprived conditions. ADN, adenosine; ETH, ethanolamine; HCS, homocysteine; hxan-D, hypoxanthine-deprived; hxan-R, hypoxanthine-rich; MET, l-methionine; SAH, S-adenosylhomocysteine; SAM, S-adenosylmethionine; SER, l-serine

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