Short-term metabolic adjustments in Plasmodium falciparum counter hypoxanthine deprivation at the expense of long-term viability

Table 1 Model-predicted changes in parasite-infected RBC metabolism

Metabolic pathway	Number of metabolic reactions
Metabolic pathway	Hypoxanthine-rich medium (90 µM)	Hypoxanthine-deprived medium (0.5 µM)
Phospholipid	7	8
Haem synthesis	7	7
Pentose phosphate pathway	1	1
Haem degradation	3	3

Statistically significant reactions, between simulations of uninfected and parasite-infected erythrocyte metabolism, computed using Student’s t-test and a criterion of p < 0.01

ISSN: 1475-2875