Short-term metabolic adjustments in Plasmodium falciparum counter hypoxanthine deprivation at the expense of long-term viability

Table 2 Plasmodium falciparum metabolic pathways altered in response to hypoxanthine deprivation

Within 24 h of infection		Past 24 h of infection
Pathway	Number of reactions	Pathway	Number of reactions
Phospholipid metabolism	10	Fatty acid synthesis	34
Porphyrin metabolism	9	Pentose phosphate cycle	7
Ubiquinone metabolism	9	Methionine polyamine metabolism	6
Isoprenoid metabolism	8	CoA biosynthesis	5
Nicotinate metabolism	7	Lipid utilization	5
Shikimate biosynthesis	7	TCA cycle	5

Reactions that significantly differed between simulations of parasite metabolism under hypoxanthine-rich and -deprived conditions, as determined by Student’s t-test and a significance criterion of p < 0.01
CoA, coenzyme A; TCA, tricarboxylic acid

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