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Table 2 Plasmodium falciparum metabolic pathways altered in response to hypoxanthine deprivation

From: Short-term metabolic adjustments in Plasmodium falciparum counter hypoxanthine deprivation at the expense of long-term viability

Within 24 h of infection Past 24 h of infection
Pathway Number of reactions Pathway Number of reactions
Phospholipid metabolism 10 Fatty acid synthesis 34
Porphyrin metabolism 9 Pentose phosphate cycle 7
Ubiquinone metabolism 9 Methionine polyamine metabolism 6
Isoprenoid metabolism 8 CoA biosynthesis 5
Nicotinate metabolism 7 Lipid utilization 5
Shikimate biosynthesis 7 TCA cycle 5
  1. Reactions that significantly differed between simulations of parasite metabolism under hypoxanthine-rich and -deprived conditions, as determined by Student’s t-test and a significance criterion of p < 0.01
  2. CoA, coenzyme A; TCA, tricarboxylic acid