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Table 1 Risk predictors of P. vivax (A) infection prevalence, (B) new infection, and (C) infection density by qPCR detection

From: Molecular epidemiology of residual Plasmodium vivax transmission in a paediatric cohort in Solomon Islands

 

Overall P. vivax prevalence (%)

(A) Prevalence

(B) New P. vivax infection

(C) P. vivax density

ORa

aOR

95% CI

IRRa

aIRR

95% CI

Coeff.a

aCoeff.

95% CI

Age

 Linear

n/a

1.16*

1.18

[1.13, 1.23]

1.18*

1.21

[1.16, 1.25]

n/a

 Quadratic

n/a

n/a

− 0.01*

0.00

[− 0.01, − 0.002]

   

p–value < 0.001

 

p-value < 0.001

 

p-value < 0.001

Villages (for details refer to Additional file 10)

1.2–47.4

0.13–8.32

0.18–6.86

[0.02, 17.52]

0.07–4.96

0.11–6.18

[0.01, 12.42]

− 0.59–0.67

− 0.66–0.35

[− 0.95, 0.98]

  

p-value < 0.001

 

p-value < 0.001

 

p-value < 0.001

ACD follow-up timepoint (for details refer to Additional file 10)

9.0–16.2

0.72–1.39

0.69–1.46

[0.50, 1.86]

0.46–0.95

0.45–0.93

[0.32, 1.28]

− 0.25–0.14

− 0.47–0.15

[− 0.73, 0.38]

  

p-value < 0.001

 

p-value < 0.001

 

p-value < 0.001

LLIN usage (per 10% increase in use)

n/a

0.94*

0.89

[0.82, 0.97]

0.97

n/a

0.03

n/a

  

p-value = 0.006

      

molFOB of P. vivax

n/a

n/a

n/a

0.02

0.02

[0.001, 0.04]

        

p-value = 0.036

Previous antimalarial record (1 year before only)

20.9

2.61*

2.03

[1.45, 2.83]

1.95*

1.52

[1.16, 1.98]

0.45*

0.24

[0.07, 0.41]

  

p-value < 0.001

 

p-v`alue = 0.002

 

p-value = 0.005

G6PD deficient

16.9

1.56*

1.77

[1.16, 2.70]

1.42

1.51

[1.05, 2.18]

−0.11

n/a

  

p-value = 0.008

 

p-value = 0.026

   

α-Thalassaemia mutationb

14.2

1.56*

n/a

1.58*

1.42

[1.10, 1.84]

−0.06

n/a

     

p-value = 0.007

   

Febrile

15.1

1.21

n/a

n/a

0.62*

0.51

[0.10, 0.92]

       

p-value = 0.014

  1. Statistical analyses used were: (A) logistic regression method for prevalence analysis, (B) negative binomial regression method for incidences of new infection analysis, and (C) linear regression method for infection density analysis
  2. OR odds ratio, aOR adjusted odds ratio, 95% CI 95% confidence intervals for adjusted estimates, IRR incidence rate ratio, aIRR adjusted incidence rate ratio, Coeff. coefficient, aCoeff. adjusted coefficient
  3. Data with asterisk (*) denotes significance (p-value < 0.05)
  4. aUnivariate data
  5. bChildren with at least one mutated α-thalassaemia gene