Table 2 Prevalence of Pfdhfr and Pfdhps haplotypes in Plasmodium falciparum isolates from Bioko Island, Equatorial Guinea

Pfdhfr (n = 167)

Wild type

CNCSI

2 (1.20, − 0.45 to 2.85)

Double mutant

CICNI

10 (5.99, 2.39 to 9.59)

Triple mutant

CIRNI

145 (86.83, 81.7 to 91.96)

Mixed type

CNC/RSI

1 (0.60, − 0.57 to 1.77)

CIC/RNI

7 (4.19, 1.15 to 7.23)

CIRS/NI

1 (0.60, − 0.57 to 1.77)

CN/IC/RS/NI

1 (0.60, − 0.57 to 1.77)

Pfdhps (n = 158)

Wild type

SAKAA

2 (1.27, − 0.48 to 3.02)

Single mutant

AAKAA

9 (5.70, 2.08 to 9.32)

SGKAA

99 (62.66, 55.12 to 70.2)

Double mutant

AGKAA

17 (10.76, 5.93 to 15.59)

SGEAA

7 (4.43, 1.22 to 7.64)

SGKAS

1 (0.63, − 0.6 to 1.86)

Triple mutant

AGKAS

4 (2.53, 0.08 to 4.98)

SGEGA

1 (0.63, − 0.6 to 1.86)

Mixed type

S/AAKAA

1 (0.63, − 0.6 to 1.86)

S/AGKAA

6 (3.80, 0.82 to 6.78)

SGK/EAA

3 (1.90, − 0.23 to 4.03)

SGKA/GA

1 (0.63, − 0.6 to 1.86)

AGKA/GA

2 (1.27, − 0.48 to 3.02)

S/AA/GKAA

3 (1.90, − 0.23 to 4.03)

S/AGKA/GA

1 (0.63, − 0.6 to 1.86)

SGK/EA/GA

1 (0.63, − 0.6 to 1.86)