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Table 2 In vitro antiplasmodial activity and cytotoxicity of crude extracts from Dichrostachys cinerea and Commiphora africana

From: In vitro and in vivo studies on anti-malarial activity of Commiphora africana and Dichrostachys cinerea used by the Maasai in Arusha region, Tanzania

Extract IC50 on D6 (µg/mL ± SD) IC50 on Dd2 (µg/mL ± SD) CC50 on LLC-MK2 (µg/mL ± SD) Selectivity index by D6
CAB-DCM 4.54 ± 1.80  > 1000  > 1000 471.00
CAS-DCM  > 1000  > 1000  > 1000 ND
CAB-MeOH  > 1000  > 1000  > 1000 ND
CAS-MeOH  > 1000  > 1000 74.56 ND
DCB-DCM 2.37 ± 0.86 11.92 ± 7.43 34.65 ± 8.36 14.63
DCS-DCM 11.47 ± 2.17  > 1000 29.44 ± 4.16 2.57
DCB-MeOH  > 1000  > 1000  > 1000 ND
DCS-MeOH 2.96 ± 1.87  > 1000 178.35 ± 371.30 60.24
QN 0.05 ± 0.01 0.06 ± 0.01   
Triton X-100    2.44 ± 0.82  
  1. Italic values represent anti-plasmodial activity
  2. Plant part: CAS: Commiphora africana whole stem; CAB: Commiphora africana stem bark; DCS: Dichrostachys cinerea whole stem; DCB: Dichrostachys cinerea stem bark
  3. QN: quinine; ND: not determined; SD: standard deviation