Table 2 Distribution (number and proportion) of genotypes (kelch13 mutations, Pfmdr1 and Pfpm2 gene copy numbers) detected in Plasmodium falciparum isolates collected from Southeast Asia and Africa in 2014–2015
Locus | Allele/haplotype | Number of isolates (%) detected in | P value | |
|---|---|---|---|---|
Asia (N = 82) | Africa (N = 355) | |||
kelch 13 | ART | 46 (67.6) | 0 (0.0) | < 10−4± |
OTH | 1 (1.5) | 10 (3.0) | ||
WT | 21 (30.9) | 322 (97.0) | ||
Pfpm2 | Single copy | 68 (86.1) | 218 (73.2) | 0.02Â¥ |
Multiple copies | 11 (13.9) | 80 (26.8) | ||
Pfmdr1 | Single copy | 74 (93.7) | 240 (78.9) | 0.002Â¥ |
Multiple copies | 5 (6.3) | 64 (21.1) | ||
Pfpm2/Pfmdr1 | Single copy/single copy | 64 (81.0) | 189 (63.4) | 0.009± |
Single copy/multiple copies | 4 (5.1) | 29 (9.7) | ||
Multiple copies/single copy | 10 (12.7) | 47 (15.8) | ||
Multiple copies/multiple copies | 1 (1.3) | 33 (11.1) | ||
kelch 13/Pfpm2/Pfmdr1 | ART/multiple copies/single copy | 7 (10.8) | 0 (0.0) | < 10−4± |
WT/multiple copies/single copy | 2 (3.0) | 43 (14.7) | ||
ART/others | 38 (57.5) | 0 (0.0) | ||
WT/others | 18 (27.3) | 241 (82.5) | ||