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Table 2 Association between age and antibodies that inhibit IE adhesion to endothelial receptors

From: Age-dependent increase in antibodies that inhibit Plasmodium falciparum adhesion to a subset of endothelial receptors

Receptor Coefficient (95% CI) P value*
Level of anti-adhesion antibodies and age
 CD36 − 0.03 (− 0.32 to 0.26) NS
 Cell. Fibronectin 0.54 (0.06 to 1.02) NS
 ICAM-1 0.69 (0.37 to 1.02) 0.0003
 Integrin αvβ3 0.08 (− 0.24 to 0.40) NS
 Integrin α3β1 0.47 (0.18 to 0.76) 0.01
 Integrin α5β1 0.13 (− 0.15 to 0.40) NS
 JAM-B 0.23 (− 0.16 to 0.61) NS
 Laminin 0.68 (0.29 to 1.08) 0.007
 PECAM-1 0.32 (− 0.03 to 0.68) NS
 P-selectin 0.31 (− 0.01 to 0.64) NS
Breadth of anti-adhesion antibodies and age
 CD36 − 0.002 (− 0.04 to 0.03) NS
 Cell. Fibronectin 0.035 (0.002 to 0.07) NS
 ICAM-1 0.037 (0.02 to 0.06) 0.01
 Integrin αvβ3 − 0.0005 (− 0.02 to 0.02) NS
 Integrin α3β1 0.015 (− 0.007 to 0.04) NS
 Integrin α5β1 0.004 (− 0.01 to 0.02) NS
 JAM-B 0.017 (− 003 to 0.04) NS
 Laminin 0.035 (0.02 to 0.05) 0.004
 PECAM-1 0.025 (0.003 to 0.050 NS
 P-selectin 0.019 (− 0.005 to 0.04) NS
  1. NS not significant
  2. * Holm corrected P value. Models adjusted for hemoglobin type (HbAA, HbAC, HbAS)