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Table 2 Association between age and antibodies that inhibit IE adhesion to endothelial receptors

From: Age-dependent increase in antibodies that inhibit Plasmodium falciparum adhesion to a subset of endothelial receptors

Receptor

Coefficient (95% CI)

P value*

Level of anti-adhesion antibodies and age

 CD36

− 0.03 (− 0.32 to 0.26)

NS

 Cell. Fibronectin

0.54 (0.06 to 1.02)

NS

 ICAM-1

0.69 (0.37 to 1.02)

0.0003

 Integrin αvβ3

0.08 (− 0.24 to 0.40)

NS

 Integrin α3β1

0.47 (0.18 to 0.76)

0.01

 Integrin α5β1

0.13 (− 0.15 to 0.40)

NS

 JAM-B

0.23 (− 0.16 to 0.61)

NS

 Laminin

0.68 (0.29 to 1.08)

0.007

 PECAM-1

0.32 (− 0.03 to 0.68)

NS

 P-selectin

0.31 (− 0.01 to 0.64)

NS

Breadth of anti-adhesion antibodies and age

 CD36

− 0.002 (− 0.04 to 0.03)

NS

 Cell. Fibronectin

0.035 (0.002 to 0.07)

NS

 ICAM-1

0.037 (0.02 to 0.06)

0.01

 Integrin αvβ3

− 0.0005 (− 0.02 to 0.02)

NS

 Integrin α3β1

0.015 (− 0.007 to 0.04)

NS

 Integrin α5β1

0.004 (− 0.01 to 0.02)

NS

 JAM-B

0.017 (− 003 to 0.04)

NS

 Laminin

0.035 (0.02 to 0.05)

0.004

 PECAM-1

0.025 (0.003 to 0.050

NS

 P-selectin

0.019 (− 0.005 to 0.04)

NS

  1. NS not significant
  2. * Holm corrected P value. Models adjusted for hemoglobin type (HbAA, HbAC, HbAS)