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Fig. 3 | Malaria Journal

Fig. 3

From: Cell-traversal protein for ookinetes and sporozoites (CelTOS) formulated with potent TLR adjuvants induces high-affinity antibodies that inhibit Plasmodium falciparum infection in Anopheles stephensi

Fig. 3

Evaluation of anti-rPfCelTOS IgG, IgG2a, and IgG2b antibody avidity in immunized mice on day 38 of the first immunization by ELISA. A significant difference was observed in the avidity index (AI) of IgG, IgG2a and IgG2b antibodies between mouse group 4 (rPfCelTOS/CpG + Poly I:C) and groups 1 (rPfCelTOS alone), 2 (rPfCelTOS/CpG), and 5 (rPfCelTOS/CFA/IFA) (P < 0.05, one-way ANOVA). AI values ≤ 30%, between 30 and 50%, and > 50% were considered as low-, intermediate- and high-avidity anti-rPfCelTOS-specific antibodies, respectively. The bars and error bars show the mean AI and standard deviation (SD) in each mouse group (n = 16), respectively. *P < 0.0001. Ag rPfCelTOS antigen, TIgG Total IgG

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Malaria Journal

ISSN: 1475-2875

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