Table 2 Functionality of CYP2D6 alleles observed in ADF samples
Functionality | Allele | ADF-NR | ADF-R | European [21] | ||
|---|---|---|---|---|---|---|
No. | % | No. | % | % | ||
Increased function (IF) | *1 × N | 0 | 0.0 | 3 | 1.4 | 0.3 |
Fully function (FF) | *1 | 40 | 41.7 | 59 | 27.1 | 37.0 |
*2 | 10 | 10.4 | 33 | 15.1 | 22.0 | |
*35 | 2 | 2.1 | 9 | 4.1 | 0.0 | |
*39 | 2 | 2.1 | 5 | 2.3 | 0.0 | |
Reduced function (RF) | *9 | 2 | 2.1 | 4 | 1.8 | 3.0 |
*10 | 3 | 3.1 | 10 | 4.6 | 2.2 | |
*41 | 12 | 12.5 | 20 | 9.2 | 8.1 | |
*59 | 0 | 0.0 | 2 | 0.9 | 0.0 | |
Non-function (NF) | *3 | 2 | 2.1 | 1 | 0.5 | 1.0 |
*4 | 19 | 19.8 | 58 | 26.6 | 20.0 | |
*5 | 0 | 0.0 | 6 | 2.8 | 3.3 | |
*6 | 2 | 2.1 | 2 | 0.9 | 1.0 | |
*7 | 0 | 0.0 | 1 | 0.5 | 0.1 | |
*20 | 0 | 0.0 | 5 | 2.3 | 0.0 | |
Unknown function | *New type | 2 | 2.1 | 0 | 0.0 | 0.0 |
Total | 16 | 96 | 218 | |||