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Table 3 McDonald–Kreitman tests on msp7D of Plasmodium knowlesi and its regions with P. vivax and P. cynomolgi orthologs as outgroup species

From: Plasmodium knowlesi clinical isolates from Malaysia show extensive diversity and strong differential selection pressure at the merozoite surface protein 7D (MSP7D)

MSP7 Polymorphic changes within P. knowlesi Fixed differences between species Neutrality index
Syn NonSyn Pk vs Pv Pk vs Pcy Pk vs Pv Pk vs Pcy
Syn NonSyn Syn NonSyn
Full-length 56 91 145 188 112 132 1.25 1.38
5′ region 18 10 47 51 52 51 0.51 0.56
Central region 16 73 31 57 15 30 2.49* 2.28*
3′ region 22 8 67 78 54 61 0.31¥ 0.32¥
  1. Syn synonymous sites, NonSyn non synonymous sites, Pk Plasmodium knowlesi, Pv Plasmodium vivax, Pcy Plasmodium cynomolgi
  2. * Fisher’s exact test P-value < 0.05; ¥ Fisher’s exact test P-value < 0.01